Reacción #730224

ord-65a9a2696d3042fda71f0ee0334b27e5

Ecuación de reacción

CC(CO)NC(=O)c1cccc(I)c1
iodobenzamide
CC(CO)NC(=O)c1cccc(I)c1
N-(2-hydroxy-1-methyl-ethyl)-3-iodobenzamide
C#CCCCC(=O)O
5-hexynoic acid
→
CC(CO)NC(=O)c1cccc(C#CCCCC(=O)O)c1
( 4 )
Rendimiento 99.0%
CC(CO)NC(=O)c1cccc(C#CCCCC(=O)O)c1
6-[3-(2-Hydroxy-1-methyl-ethylcarbamoyl)phenyl]-hex-5-ynoic acid
Rendimiento 99.0%

Reactantes

CC(CO)NC(=O)c1cccc(I)c1
iodobenzamide
CC(CO)NC(=O)c1cccc(I)c1
N-(2-hydroxy-1-methyl-ethyl)-3-iodobenzamide
C#CCCCC(=O)O
5-hexynoic acid

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

The iodobenzamide (1)(2.00 g, 6.5 mmol) was coupled with 5-hexynoic acid using method B yielding (4)(1.87 g, 6.42 mmol; 99% yield).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07696382B2uspto-grants-2010_04