Reacción #72925

Ecuación de reacción

N′-(1-acetylpiperidin-4-ylidene)benzohydrazide

diethylether

→

title compound

Rendimiento 92.0%

N′-(1-acetylpiperidin-4-yl)benzohydrazide

Rendimiento 92.0%

Disolventes

acetic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe catalyst was then filtered on celite
2. 2
   Otrothe filtrate evaporated in vacuo
3. 3
   workup.DISSOLUTIONThe residue was redissolved with dichloromethane
4. 4
   Lavadowashed with aqueous NaHCO3
5. 5
   SecadoThe solvent was dried over sodium sulfate
6. 6
   Otroremoved under reduced pressure
7. 7
   Otroto give

Procedimiento

30 g (0.12 mol) of N′-(1-acetylpiperidin-4-ylidene)benzohydrazide were dissolved in 500 mL of glacial acetic acid and 1 g of PtO2 were added. The mixture was hydrogenated at 40 psi for 12 hours at room temperature. The catalyst was then filtered on celite and the filtrate evaporated in vacuo. The residue was redissolved with dichloromethane and washed with aqueous NaHCO3. The solvent was dried over sodium sulfate and removed under reduced pressure to give, after trituration with diethylether, 28.6 g (92% yield) of the title compound.

Fuente