Reacción #72924

Ecuación de reacción

diethylether

1-acetyl-4-piperidone

benzoylhydrazine

→

title compound

Rendimiento 83.0%

N′-(1-acetylpiperidin-4-ylidene)benzohydrazide

Rendimiento 83.0%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe resulting solution was refluxed for 6 hours
2. 2
   OtroThe solvent was then removed in vacuo
3. 3
   Otrothe residue partitioned between dichloromethane and water
4. 4
   SecadoThe organic layer was dried over sodium sulfate
5. 5
   Otroevaporated to dryness

Procedimiento

20 g (0.142 mol) of 1-acetyl-4-piperidone were dissolved in 400 mL of absolute ethanol and 21.2 g (0.156 mol) of benzoylhydrazine were added. The resulting solution was refluxed for 6 hours under stirring. The solvent was then removed in vacuo and the residue partitioned between dichloromethane and water. The organic layer was dried over sodium sulfate and evaporated to dryness. The residue was triturated with diethylether and 30 g (83% yield) of the title compound were collected by filtration.

Fuente