Reacción #72918

Ecuación de reacción

1-tert-butyl-4-(4-nitrophenyl)piperazine

ammonium chloride

→

amine

Rendimiento 89.6%

4-(4-tert-butylpiperazin-1-yl)phenylamine

Rendimiento 89.6%

Disolventes

methanol

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe suspension was cooled
2. 2
   Filtraciónfiltered
3. 3
   workup.ADDITIONpH was adjusted to 10 through portionwise addition of Na2CO3 to the aqueous phase
4. 4
   ExtracciónExtraction with dichloromethane

Procedimiento

To a solution of 840 mg (3.189 mmol) of 1-tert-butyl-4-(4-nitrophenyl)piperazine in 24 mL of methanol, 904 mg (16.9 mmol) of ammonium chloride dissolved in 6 mL of water and 552 mg (9.886 mmol) of iron were added. After 7 hours, the suspension was cooled and filtered. pH was adjusted to 10 through portionwise addition of Na2CO3 to the aqueous phase. Extraction with dichloromethane yielded 667 mg of the title amine.

Fuente