Reacción #72903

Ecuación de reacción

ethyl 2-(3-aminopropyl)-8-anilino-4,5-dihydro-2H-pyrazolo[4,3-h]quinazoline-3-carboxylate hydrochloride

cesium carbonate

→

title compound

Rendimiento 70.0%

2-anilino-5,6,8,9,10,11-hexahydro-7H-[1,4]diazepino[1′,2′:1,5]pyrazolo[4,3-h]quinazolin-7-one

Rendimiento 70.0%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrowas removed at reduced pressure
2. 2
   workup.ADDITIONWater was then added to the residue
3. 3
   Filtraciónthe solid collected by filtration
4. 4
   Lavadowashed with water and acetone

Procedimiento

185 mg (0.43 mmol) of ethyl 2-(3-aminopropyl)-8-anilino-4,5-dihydro-2H-pyrazolo[4,3-h]quinazoline-3-carboxylate hydrochloride were dissolved in 10 mL of methanol and 400 mg of cesium carbonate were added. After 3 hours under stirring at room temperature the solvent was removed at reduced pressure. Water was then added to the residue and the solid collected by filtration and washed with water and acetone to give 100 mg (70% yield) of the title compound.

Fuente