Reacción #7281

Ecuación de reacción

4-hydroxymethyl-benzaldehyde

2-aminopyridine

acetic acid

sodium triacetoxyborohydride

→

title compound

Rendimiento 74.0%

[4-(Pyridin-2-ylaminomethyl)-phenyl]-methanol

Rendimiento 74.0%

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroone hour at 50° C., followed by purification of crude material

Procedimiento

Using general procedure B: Reaction of 4-hydroxymethyl-benzaldehyde (1.01 g, 7.42 mmol), 2-aminopyridine (697 mg, 7.42 mmol), acetic acid (0.5 mL) and sodium triacetoxyborohydride (3.2 g, 14.8 mmol) in THF (20 mL) at room temperature under N2 for 40 min., then one hour at 50° C., followed by purification of crude material using chromatography on silica gel (2:2:96 CH3OH—NH3 H2O—CH2Cl2), afforded the title compound (1.17 g, 74%) as white foam.

Fuente