Reacción #728027

Ecuación de reacción

H2SO4

HNO3

(4-Bromo-phenyl)-(4-nitro-phenyl)-methanone

→

(4-Bromo-3-nitro-phenyl)-(-4-nitro-phenyl)-methanone

Rendimiento 78.0%

Disolventes

dichloroethane

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGto stir
2. 2
   Otroresulting in precipitation of the product
3. 3
   FiltraciónThe product was filtered
4. 4
   Otrodried

Procedimiento

The crude (4-Bromo-phenyl)-(4-nitro-phenyl)-methanone (15 g, 49 mmol) was dissolved in 45 mL of dichloroethane and added dropwise via addition funnel to a mixture of concentrated H2SO4(aq) (21 mL, 392 mmol) and fuming HNO3(aq) (15.7 mL, 392 mmol). The mixture was stirred at 60° C. overnight. Subsequently the mixture was poured over ice water and allowed to stir resulting in precipitation of the product. The product was filtered and dried affording 78% yield of the desired (4-Bromo-3-nitro-phenyl)-(-4-nitro-phenyl)-methanone (13.1 g, 38 mmol).

Fuente