Reacción #72760

Ecuación de reacción

6-bromo-2-isopropyl-4-nitro-1H-benzo[d]imidazole

1-(bromomethyl)naphthalene

K2CO3

→

crude product

Rendimiento 102.6%

6-bromo-2-(1-methylethyl)-1-(1-naphthalenylmethyl)-4-nitro-1H-benzimidazole

Rendimiento 102.6%

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaIt was cooled to room temperature
2. 2
   Filtraciónfiltered
3. 3
   workup.ADDITIONThe filtrate was then poured into water (1 L)
4. 4
   FiltraciónIt was then filtered
5. 5
   Otroto afford a solid
6. 6
   Lavadothat was washed with water
7. 7
   Otrodried in-vacuo

Procedimiento

A mixture of 6-bromo-2-isopropyl-4-nitro-1H-benzo[d]imidazole (4.7 g), 1-(bromomethyl)naphthalene (4.01 g) and K2CO3 (4.55 g) in DMF (150 mL) was stirred at 80° C. for 2 h. It was cooled to room temperature and filtered. The filtrate was then poured into water (1 L). It was then filtered to afford a solid that was washed with water and then dried in-vacuo to afford the crude product (7.2 g). LC-MS: m/e=425 [M+1]+

Fuente