Reacción #72683

Ecuación de reacción

N,N-bis(4-methoxybenzyl)-4-(4-methoxybenzylamino)-2-oxo-1,2-dihydroquinoline-3-carboxamide

→

crude final product

4-amino-2-oxo-1,2-dihydroquinoline-3-carboxamide

Disolventes

TFA

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe TFA was removed under vacuum
2. 2
   workup.STIRRINGthe resultant solid was stirred in water overnight
3. 3
   Filtracióncollected by filtration

Procedimiento

N,N-bis(4-methoxybenzyl)-4-(4-methoxybenzylamino)-2-oxo-1,2-dihydroquinoline-3-carboxamide (Example 74a) (2.0 g, 3.55 mmol) was dissolved in TFA (15 mL) and the solution was stirred at room temperature for 6 hours. The TFA was removed under vacuum, and the resultant solid was stirred in water overnight, then collected by filtration to give 1.8 grams of crude final product. 1H NMR (400 MHz, DMSO-d6) δ7.18 (m, 2H), 7.25 (d, J=7.2 Hz, 1H), 7.56 (t, J=8.0 Hz, 1H), 8.09 (d, J=7.6 Hz, 2H), 9.83 (d, J=4.8 Hz, 1H), 10.85 (bs, 1H), 11.12 (s, 1H). MS 204 (MH+).

Fuente