Reacción #725897

Ecuación de reacción

[2-(4-Nitrophenoxy)-ethoxy]acetic acid methyl ester

→

23

Rendimiento 71.1%

[2-(4-Amino-phenoxy)-ethoxy]-acetic acid methyl ester

Rendimiento 71.1%

Disolventes

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe catalyst was filtered
2. 2
   Concentraciónthe filtrate concentrated
3. 3
   workup.ADDITIONhexane (3 ml) added
4. 4
   Filtraciónthe solid filtered

Procedimiento

[2-(4-Nitrophenoxy)-ethoxy]acetic acid methyl ester 22 (1 g, 3.9 mmol) was dissolved in anhydrous ethyl acetate (20 ml), palladium carbon (10%, 0.1 g) added and the mixture stirred under an atmosphere of hydrogen using balloon for 30 minutes. The catalyst was filtered, the filtrate concentrated, hexane (3 ml) added, and the solid filtered to give 23 (625 mg, 70.9%) as a light brown powder. The melting point was found to be 51-52.5° C. The structure was confirmed with IR and NMR.

Fuente