Reacción #725891

Ecuación de reacción

2-(4-Acetylaminophenoxy)propionic acid methyl ester

2-(4-Acetylamino-phenoxy)-propionic acid methyl ester

→

17

Rendimiento 98.1%

2-(4-Amino-phenoxy)-propionic acid

Rendimiento 98.1%

Disolventes

hydrochloric acid

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas refluxed for 48 hours
2. 2
   workup.DISTILLATIONExcess concentrated hydrochloric acid was distilled off in vacuum
3. 3
   Filtraciónfiltered hot
4. 4
   Filtraciónfiltered
5. 5
   Otrodried

Procedimiento

A mixture of 2-(4-Acetylaminophenoxy)propionic acid methyl ester 16 (320 grams, 1.35 mol) in concentrated hydrochloric acid (8 liters) was refluxed for 48 hours. Excess concentrated hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 17 (240 g, 81.7%) as a brown powder. The melting point was found to be 175-180° C.

Fuente