Reacción #72564

Ecuación de reacción

2-bromo-1-(4-chloro-phenyl)-ethanone

potassium formate

→

title product

1-(4-Chloro-phenyl)-2-hydroxy-ethanone

Disolventes

MeOH

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaat reflux for 3 hours
2. 2
   workup.ADDITIONThe reaction mixture is poured
3. 3
   Otroonto crushed ice
4. 4
   OtroThe solid formed
5. 5
   Filtraciónis filtered off
6. 6
   Lavadowashed with cold MeOH
7. 7
   Otrodried in vacuo

Procedimiento

A mixture of 2-bromo-1-(4-chloro-phenyl)-ethanone (100 mmoles) and potassium formate (130 mmoles) in MeOH (100 ml) is stirred at reflux for 3 hours. The reaction mixture is poured onto crushed ice. The solid formed is filtered off, washed with cold MeOH and then dried in vacuo to yield the title product, which is used directly in the next Step.

Fuente