Reacción #72560

Ecuación de reacción

2-bromo-1-(4-chloro-phenyl)-ethanone

hydrazine-carbothioic acid O-ethyl ester

→

title product

5-(4-Chloro-phenyl)-3,6-dihydro-[1,3,4]thiadiazin-2-one

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solid formed
2. 2
   Filtraciónis filtered off
3. 3
   Lavadowashed with acetonitrile and ethyl ether
4. 4
   Otrodried in vacuo

Procedimiento

A mixture of 2-bromo-1-(4-chloro-phenyl)-ethanone (90.71 mmoles) and hydrazine-carbothioic acid O-ethyl ester (90.71 mmoles) in acetonitrile (84 ml) is stirred at ambient temperature for 3 hours. The solid formed is filtered off, washed with acetonitrile and ethyl ether and then dried in vacuo to yield the title product, which is used directly in the next Step.

Fuente