Reacción #72528

Ecuación de reacción

morpholine

pyrrole

NaOH

Formaldehyde

→

title product

4-(1H-Pyrrol-2-ylmethyl)-morpholine

Disolventes

acetic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe solution is cooled to 0° C.
2. 2
   ExtracciónAfter extraction with DCM
3. 3
   Lavadothe organic phases are washed with water and with saturated aqueous NaCl solution
4. 4
   Secadodried over sodium sulphate
5. 5
   Filtraciónfiltered
6. 6
   Otroevaporated to dryness

Procedimiento

To a solution of morpholine (22 mmoles) in acetic acid (10 ml) there is added pyrrole (20 mmoles) dropwise at 0° C. Formaldehyde (37% aq., 20 mmoles) is then added dropwise. The reaction mixture is stirred for 2 hours at ambient temperature. The solution is cooled to 0° C. and is brought to alkaline pH (10-11) using 20% aqueous NaOH solution. After extraction with DCM, the organic phases are washed with water and with saturated aqueous NaCl solution, dried over sodium sulphate, filtered and evaporated to dryness to yield the title product in the form of a white solid which is used directly in the next Step.

Fuente