Reacción #72075

Ecuación de reacción

2,4-Dinitrobenzonitrile

Potassium carbonate

ethyl thioglycolate

→

title compound

Rendimiento 32.4%

Ethyl 3-amino-6-nitro-1-benzothiophene-2-carboxylate

Rendimiento 32.4%

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe reaction solution was concentrated under reduced pressure
2. 2
   workup.ADDITIONdiluted with ethyl acetate
3. 3
   Lavadowashed with water
4. 4
   Secadodried over anhydrous sodium sulfate
5. 5
   Concentraciónconcentration under reduced pressure
6. 6
   Otrothe residue was recrystallized from ethyl acetate/hexane

Procedimiento

2,4-Dinitrobenzonitrile (5.08 g, 26.3 mmol) was dissolved in DMF (55 ml). Potassium carbonate (4.36 g, 31.6 mmol) and ethyl thioglycolate (3.17 g, 26.3 mmol) were added, and the mixture was stirred at room temperature for three days. The reaction solution was concentrated under reduced pressure, diluted with ethyl acetate, washed with water, and dried over anhydrous sodium sulfate. Following concentration under reduced pressure, the residue was recrystallized from ethyl acetate/hexane to obtain 2.27 g of the title compound as crystals (32%).

Fuente