Reacción #72044

Ecuación de reacción

cesium carbonate

benzyl cis(±)-[3-methoxypiperidin-4-yl]carbamate hydrochloride

ethyl 4-chloro-6-methylpyridine-2-carboxylate

BINAP

→

title compound

Rendimiento 34.5%

Methyl cis(±)-4-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-6-methylpyridine-2-carboxylate

Rendimiento 34.5%

Condiciones de reacción

Procedimiento

The same operation as in Example (42a) was performed using benzyl cis(±)-[3-methoxypiperidin-4-yl]carbamate hydrochloride obtained in Example (160a) (409 mg, 1.36 mmol), ethyl 4-chloro-6-methylpyridine-2-carboxylate (272 mg, 1.36 mmol), palladium acetate (30.6 mg, 0.14 mmol), BINAP (169 mg, 0.27 mmol) and cesium carbonate (1.33 g, 4.08 mmol), to obtain 194 mg of the title compound as a yellow oily substance.

Fuente