Reacción #72033

Ecuación de reacción

cesium carbonate

benzyl cis(±)-[3-methoxypiperidin-4-yl]carbamate hydrochloride

ethyl 5-bromopyridine-3-carboxylate

BINAP

→

title compound

Rendimiento 51.2%

Ethyl cis(±)-5-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)pyridine-3-carboxylate

Rendimiento 51.2%

Condiciones de reacción

Procedimiento

The same operation as in Example (160b) was performed using benzyl cis(±)-[3-methoxypiperidin-4-yl]carbamate hydrochloride obtained in Example (160a) (832 mg, 2.76 mmol), ethyl 5-bromopyridine-3-carboxylate (530 mg, 2.3 mmol), palladium acetate (51.72 mg, 0.23 mmol), BINAP (286.89 mg, 0.46 mmol), and cesium carbonate (2.25 g, 6.91 mmol), to obtain 487 mg of the title compound as a yellow oily substance.

Fuente