Reacción #72023

Ecuación de reacción

Water

Triethylamine

1,1′-carbonylbis-1H-imidazole

L-proline methyl ester hydrochloride

→

title compound

Rendimiento 100.0%

1-(1H-Imidazol-1-ylcarbonyl)-L-proline methyl ester

Rendimiento 100.0%

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónfollowed by extraction with dichloromethane
2. 2
   LavadoThen, the organic layer was washed with brine
3. 3
   Secadodried over anhydrous sodium sulfate
4. 4
   Concentraciónconcentration under reduced pressure

Procedimiento

L-proline methyl ester hydrochloride (0.300 g, 1.81 mmol) was dissolved in dichloromethane (5 ml). Triethylamine (0.202 g, 1.99 mmol) and 1,1′-carbonylbis-1H-imidazole (0.352 g, 2.17 mmol) were added, and the mixture was stirred at room temperature for five days. Water was added to the reaction solution, followed by extraction with dichloromethane. Then, the organic layer was washed with brine and dried over anhydrous sodium sulfate. Following concentration under reduced pressure, 0.404g of the title compound was obtained as a colorless oily substance (100%).

Fuente