Reacción #72016

Ecuación de reacción

tert-butyl cis(±)-4-(benzylamino)-3-isopropoxypiperidine-1-carboxylate

tert-Butyl cis(±)-4-(benzylamino)-3-isopropoxypiperidine-1-carboxylate

→

tert-butyl cis(±)-4-amino-3-isopropoxypiperidine-1-carboxylate

Rendimiento 83.0%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe catalyst was filtered off
2. 2
   Concentraciónthe filtrate was concentrated under reduced pressure
3. 3
   workup.ADDITIONA 1 N aqueous sodium hydroxide solution was added to the resulting residue
4. 4
   Extracciónthe organic substance was extracted with ethyl acetate
5. 5
   SecadoThe organic layer was dried over magnesium sulfate
6. 6
   Otrothe solvent was evaporated under reduced pressure

Procedimiento

20% palladium hydroxide (wet, 60 mg) was added to a solution of tert-butyl cis(±)-4-(benzylamino)-3-isopropoxypiperidine-1-carboxylate obtained in Example (147d) (120 mg, 0.345 mmol) in methanol (1.2 mL), and the mixture was catalytically hydrogenated at room temperature for three hours. The catalyst was filtered off, and then the filtrate was concentrated under reduced pressure. A 1 N aqueous sodium hydroxide solution was added to the resulting residue, and the organic substance was extracted with ethyl acetate. The organic layer was dried over magnesium sulfate, and the solvent was evaporated under reduced pressure to obtain 74 mg of tert-butyl cis(±)-4-amino-3-isopropoxypiperidine-1-carboxylate as a colorless oily substance (83%). The resulting amine was dissolved in DMF (1 mL). 4-Chloro-5-ethyl-1H-imidazole-2-carboxylic acid (described in Example 1d, 54 mg, 0.29 mmol) was added, and the mixture was cooled in an ice water bath. 1-Hydroxybenzotriazole (44 mg, 0.31 mmol) and 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride (60 mg, 0.31 mmol) were added thereto, and the mixture was stirred at room temperature overnight. The reaction solution was diluted with ethyl acetate, sequentially washed with brine, water and brine, and dried over magnesium sulfate. The solvent was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography (elution solvent: chloroform/methanol) to obtain 60.6 mg of the title compound as a colorless solid (50%).

Fuente