Reacción #71558

Ecuación de reacción

4-nitrophenol

triethylamine

ethyl acetate

water

→

butyl 4-nitrophenyl carbonate

Disolventes

tetrahydrofuran

butyl chloroformate

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaunder cooling on ice
2. 2
   OtroThe organic layer was separated
3. 3
   Lavadowashed with a saturated sodium chloride aqueous solution
4. 4
   Secadodried over anhydrous magnesium sulfate
5. 5
   OtroAfter removing the solvent
6. 6
   Otroby evaporation under reduced pressure

Procedimiento

Into a solution of 3.00 g of 4-nitrophenol and 3.31 mL of triethylamine in 30 mL of tetrahydrofuran, 2.75 mL of butyl chloroformate was dropped under cooling on ice. To the reaction mixture, after stirred at the same temperature for 10 min, ethyl acetate and water were added. The organic layer was separated, washed with a saturated sodium chloride aqueous solution, and dried over anhydrous magnesium sulfate. After removing the solvent by evaporation under reduced pressure, 4.60 g of butyl 4-nitrophenyl carbonate was obtained as a light yellow oily matter.

Fuente