Reacción #7137

ord-4c400ad91b144176b231fe597fdc5691

Ecuación de reacción

NC(=O)[C@@H]1CCCC[C@H]1NS(=O)(=O)c1ccc(Cl)cc1
trans-2-(4-chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid amide
FC(F)(F)Oc1ccc(CBr)cc1
1-bromomethyl-4-trifluoromethoxy-benzene
→
NC(=O)[C@@H]1CCCC[C@H]1N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(Cl)cc1
titled compound
Rendimiento 20.0%
NC(=O)[C@@H]1CCCC[C@H]1N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(Cl)cc1
trans-2-[(4-Chlorobenzenesulfonyl)-(4-trifluoromethoxy-benzyl)-amino]-cyclohexanecarboxylic acid amide
Rendimiento 20.0%

Reactantes

NC(=O)[C@@H]1CCCC[C@H]1NS(=O)(=O)c1ccc(Cl)cc1
trans-2-(4-chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid amide
FC(F)(F)Oc1ccc(CBr)cc1
1-bromomethyl-4-trifluoromethoxy-benzene

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

The titled compound was prepared in 20% yield from trans-2-(4-chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid amide and 1-bromomethyl-4-trifluoromethoxy-benzene according to the procedure described in Example 11: 1H NMR (DMSO-d6) δ 7.63 (d, 2 H, J=8.0 Hz), 7.43 (m, 4 H), 7.37 (s br, 1 H), 7.18 (d, 2 H, J=8.0 Hz), 6.81 (s br, 1 H), 4.36 (AB2, 2 H,Δv=12,Jab=72 Hz), 4.01 (s br, 1 H), 1.83 (m, 1 H), 1.30 (m, 8 H); MS m/e 490.97 (M+H)+.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07084178B2uspto-grants-2006_08