Reacción #71366

Ecuación de reacción

8-benzo[b]thiophen-3-yl-quinoxaline-5-carboxylic acid

5-(4-methyl-piperazin-1-ylmethyl)-pyridin-2-ylamine hydrochloride

8-(2,6-Dichloro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [5-(4-methyl-piperazin-1-ylmethyl)-pyridin-2-yl]amide

benzothiophene-3-boronic acid

TBTU

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Title compound

8-Benzo[b]thiophen-3-yl-quinoxaline-5-carboxylic acid [5-(4-methyl-piperazin-1-ylmethyl)-pyridin-2-yl]-amide

Disolventes

DCM MeOH

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe title compound was prepared in analogy to the procedure

Procedimiento

The title compound was prepared in analogy to the procedure described in Step 14.1 but stirring the reaction mixture at it overnight and using 2 equiv of 5-(4-methyl-piperazin-1-ylmethyl)-pyridin-2-ylamine hydrochloride (Example 31), TBTU (2 equiv) and 8-benzo[b]thiophen-3-yl-quinoxaline-5-carboxylic acid. The carboxylic acid was synthesized as described in Steps 1.2-1.7 but using benzothiophene-3-boronic acid in Step 1.4. Title compound: ESI-MS: 494.9 [M+H]+; tR=3.77 min (System 1); TLC: Rf=0.17 (DCM/MeOH, 9:1).

Fuente