Reacción #713351

Ecuación de reacción

(4-(3-(pyrrolidin-1-yl)propyl)phenyl)(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)methanone

propiophenone

→

desired product

Rendimiento 25.3%

4-(2-phenyl-1-(4-(3-(pyrrolidin-1-yl)propyl)phenyl)but-1-enyl)-phenol

Rendimiento 25.3%

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrogeneral procedure of McMurry reaction

Procedimiento

Following general procedure of McMurry reaction as described in example 1, step B, (4-(3-(pyrrolidin-1-yl)propyl)phenyl)(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)methanone (798 mg, 2 mmol) was reacted with propiophenone (800 mg, 6 mmol) to give 208 mg desired product (25%, Z/E=1/1). m/z=412[M+1]+.

Fuente