Reacción #713350

Ecuación de reacción

(4-(3-(pyrrolidin-1-yl)prop-1-ynyl)phenyl)(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)methanone

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product

Rendimiento 95.3%

(4-(3-(pyrrolidin-1-yl)propyl)phenyl)(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)methanone

Rendimiento 95.3%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónAfter complete conversion (TLC monitoring), the catalyst was filtered off through a pad of celite
2. 2
   Lavadowashed with EtOAc
3. 3
   ConcentraciónThe filtrate was concentrated under reduced pressure

Procedimiento

A flask was charged with (4-(3-(pyrrolidin-1-yl)prop-1-ynyl)phenyl)(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)methanone (391 mg, 1 mmol), Riney Ni (0.2 eq), and 20 mL of methanol. The mixture was stirred under hydrogen at room temperature and atmospheric pressure for 2 h. After complete conversion (TLC monitoring), the catalyst was filtered off through a pad of celite, and washed with EtOAc. The filtrate was concentrated under reduced pressure to give the product (375 mg, 95% yield).

Fuente