Reacción #7120

Ecuación de reacción

cis-2-Aminocyclohexanecarboxylic acid methyl ester

ammonium hydroxide

→

cis-2-aminocyclohexanecarboxylic acid amide

Disolventes

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe reaction was concentrated to dryness in vacuo
2. 2
   Otroazeotroped with toluene (50 mL)
3. 3
   OtroThe crude product, cis-2-aminocyclohexanecarboxylic acid amide, was used in the next reaction without purification

Procedimiento

cis-2-Aminocyclohexanecarboxylic acid methyl ester (2.20 g, 14.0 mmol) was treated with aqueous ammonium hydroxide (40 mL) in toluene (40 mL) and stirred vigorously at room temperature for 16 h. The reaction was concentrated to dryness in vacuo and azeotroped with toluene (50 mL). The crude product, cis-2-aminocyclohexanecarboxylic acid amide, was used in the next reaction without purification: 1H NMR (400 MHz, DMSO-d6) δ 7.78 (2 H, s br), 7.67 (s, 1 H), 7.25 (s, 1 H), 1.87 (m, 2 H), 1.60 (m, 4 H), 1.41 (m, 4 H).

Fuente