Reacción #710526

Ecuación de reacción

Compound I

2-(1,3-benzodioxol-5-yl)-2-methyl propanal

NH2OH

pyridine

→

Compound J

Rendimiento 96.0%

2-(1,3-benzodioxol-5-yl)-2-methyl propanal oxime

Rendimiento 96.0%

Disolventes

ethanol

HCl

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe reaction mixture was evaporated to dryness
2. 2
   workup.ADDITIONadded 10 mL of ethyl acetate
3. 3
   LavadoThe organic layer was washed with distilled water
4. 4
   Secadodried over anhydrous sodium sulfate
5. 5
   Filtraciónfiltered
6. 6
   Otroevaporated
7. 7
   OtroThe crude reaction mixture
8. 8
   Otrowas purified over silica gel column

Procedimiento

To a solution of Compound I (511 mg, 2.66 mmol) in ethanol (1 mL), HCl.NH2OH (277 mg, 4.00 mmol) and pyridine (2.2 mL, 26.58 mmol) were added and it was stirred at room temperature for 1.5 hours. The reaction mixture was evaporated to dryness and added 10 mL of ethyl acetate. The organic layer was washed with distilled water, dried over anhydrous sodium sulfate, filtered and evaporated. The crude reaction mixture was purified over silica gel column using 5:1 petroleum ether-ethyl acetate as solvent to afford Compound J (528 mg, 96%) as a white foam.

Fuente