Reacción #710503

ord-09beeee2505841458329c4dc2d85ed28

Ecuación de reacción

O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
O=C([O-])O.[Na+]
sodium bicarbonate
→
O=C(O)CC(O)(CC(=O)O)C(=O)O.O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].[Na+].[Na+].[Na+]
Sodium Citrate Citric Acid

Reactantes

O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
O=C([O-])O.[Na+]
sodium bicarbonate

Reactivos

Ninguno

Disolventes

O
water
O
water

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    Otroreaction
  2. 2
    Otrofor the reaction
  3. 3
    OtroCarbon dioxide is evaporated rapidly
  4. 4
    Otrowater is gradually evaporated
  5. 5
    workup.ADDITIONa mixture of 87% Sodium citrate and 13% citric acid active ingredient
  6. 6
    OtroThe product is then dried
  7. 7
    Otrocrushed to fine particles
  8. 8
    Otroto produce an active composition suitable for formulation into the pharmacological formulations of this invention

Procedimiento

Mix one part citric acid and one part sodium bicarbonate than gradually spray sterile water into the mixture to make reaction. The water is merely the medium for the reaction. Carbon dioxide is evaporated rapidly and water is gradually evaporated. The remaining product is a mixture of 87% Sodium citrate and 13% citric acid active ingredient. The product is in the form of crystals. The product is then dried and crushed to fine particles to produce an active composition suitable for formulation into the pharmacological formulations of this invention.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US09301935B2uspto-grants-2016_04