Reacción #710470

Ecuación de reacción

2-bromo-5-methylpyridine

N-bromosuccinimide

→

2-bromo-5-bromomethylpyridine

Rendimiento 20.0%

Disolventes

carbon tetrachloride

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe resulting mixture was heated
2. 2
   Temperaturarefluxed for 19 hours
3. 3
   Otrowas returned to room temperature
4. 4
   Concentraciónconcentrated under reduced pressure
5. 5
   Otropurified by silica gel column chromatography (hexane:ethyl acetate=19:1)

Procedimiento

500 mg (2.92 mmol) of 2-bromo-5-methylpyridine was dissolved in 15 ml of carbon tetrachloride, 623 mg (3.50 mmol) of N-bromosuccinimide and 10 mg of benzoyl peroxide were added thereto, and the resulting mixture was heated and refluxed for 19 hours. After the reaction was completed, the reaction solution was returned to room temperature, concentrated under reduced pressure and purified by silica gel column chromatography (hexane:ethyl acetate=19:1) to obtain 143 mg (yield 20%) of 2-bromo-5-bromomethylpyridine.

Fuente