Reacción #70946

Ecuación de reacción

3,4-dimethoxy-5-nitro-benzoyl chloride

methylamine

→

3,4-dimethoxy-N-methyl-5-nitro-benzamide

Disolventes

dichloromethane

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadowashed with water
2. 2
   SecadoThe organic phase was dried over anhydrous magnesium sulphate
3. 3
   Filtraciónfiltered
4. 4
   Otroevaporated to dryness
5. 5
   Otroto leave a crude residue that
6. 6
   Otrowas recrystallised from a dichloromethane/isopropanol mixture

Procedimiento

To a stirred solution of 3,4-dimethoxy-5-nitro-benzoyl chloride (0.50 g, 2.04 mmol) in dichloromethane (10 mL) at 0° C., was added dropwise methylamine (1.02 mL, 2.04 mmol, 2 M in THF). The reaction mixture was stirred at room temperature till all starting material disappeared, then diluted with dichloromethane and washed with water. The organic phase was dried over anhydrous magnesium sulphate, filtered and evaporated to dryness to leave a crude residue that was recrystallised from a dichloromethane/isopropanol mixture to afford 3,4-dimethoxy-N-methyl-5-nitro-benzamide, 0.44 g (89%).

Fuente