Reacción #70944

Ecuación de reacción

2-(trifluoromethyl)pyridine-3-carbothioamide

1-[3,4-bis(benzyloxy)-5-nitrophenyl]-2-bromoethanone

→

4-(3,4-bis(benzyloxy)-5-nitrophenyl)-2-(2-(trifluoromethyl)pyridin-3-yl)thiazole

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONthe reaction mixture was poured onto water (50 mL)
2. 2
   FiltraciónThe resulting precipitate was filtered off
3. 3
   Lavadowashed with water (25 mL)
4. 4
   Otrodried
5. 5
   OtroRecrystallisation from dichloromethane/isopropanol

Procedimiento

A mixture of 2-(trifluoromethyl)pyridine-3-carbothioamide (0.227 g, 1.10 mmol) and 1-[3,4-bis(benzyloxy)-5-nitrophenyl]-2-bromoethanone (0.50 g, 1.10 mmol) were refluxed overnight in absolute ethanol (5 mL). After cooling to room temperature, the reaction mixture was poured onto water (50 mL). The resulting precipitate was filtered off, washed with water (25 mL) and dried. Recrystallisation from dichloromethane/isopropanol afforded 4-(3,4-bis(benzyloxy)-5-nitrophenyl)-2-(2-(trifluoromethyl)pyridin-3-yl)thiazole, 0.539 g (87%).

Fuente