Reacción #70937

Ecuación de reacción

(E)-N-((dimethylamino)methylene)-3,4-dimethoxy-5-nitrobenzamide

2-(trifluoromethyl)nicotinimidamide

→

2-(3,4-dimethoxy-5-nitrophenyl)-4-(2-(trifluoromethyl)pyridin-3-yl)-1,3,5-triazine

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction mixture was heated
2. 2
   Temperaturato reflux for 5 hours
3. 3
   Otrothe solvent was removed by evaporation
4. 4
   workup.DISSOLUTIONThe residue was then dissolved in a dichloromethane/isopropanol mixture (50 mL, 70:30)
5. 5
   Lavadothe organic phase was washed with water
6. 6
   Secadodried over anhydrous magnesium sulphate
7. 7
   Filtraciónfiltered
8. 8
   Otroevaporated
9. 9
   OtroThe crude product was recrystallized from ethanol

Procedimiento

To a solution of (E)-N-((dimethylamino)methylene)-3,4-dimethoxy-5-nitrobenzamide (1.12 g, 4 mmol) ethanol (30 mL) was added 2-(trifluoromethyl)nicotinimidamide (0.756 g, 4 mmol). The reaction mixture was heated to reflux for 5 hours. It was cooled to room temperature and the solvent was removed by evaporation. The residue was then dissolved in a dichloromethane/isopropanol mixture (50 mL, 70:30) and the organic phase was washed with water, dried over anhydrous magnesium sulphate, filtered and evaporated. The crude product was recrystallized from ethanol to give 2-(3,4-dimethoxy-5-nitrophenyl)-4-(2-(trifluoromethyl)pyridin-3-yl)-1,3,5-triazine, 1.221 g (75%).

Fuente