Reacción #709269

Ecuación de reacción

2-methyl-8a-morpholino-3-nitro-4-(2-trifluoromethylphenyl)-4a,5,6,7,8,8a-hexahydro-4H-chromene

methylammonium chloride

→

1,2-Dimethyl-3-nitro-4-(2-trifluoromethylphenyl)-1,4,5,6,7,8-hexahydroquinoline

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter cooling
2. 2
   Filtraciónthe salts are filtered off with suction
3. 3
   Otrothe solution is evaporated
4. 4
   Lavadothe mixture is washed with water
5. 5
   OtroThe organic phase is dried
6. 6
   Concentraciónconcentrated
7. 7
   Otrothe residue is chromatographed on silica gel with chloroform with 1% of methanol
8. 8
   OtroIntensely yellow crystals are obtained from ethanol

Procedimiento

2 g (4.7 mmol) of 2-methyl-8a-morpholino-3-nitro-4-(2-trifluoromethylphenyl)-4a,5,6,7,8,8a-hexahydro-4H-chromene are heated at the reflux temperature in 15 ml of ethanol with 2 g of methylammonium chloride for 6 hours. After cooling, the salts are filtered off with suction, the solution is evaporated, the residue is taken up in chloroform and the mixture is washed with water. The organic phase is dried and concentrated and the residue is chromatographed on silica gel with chloroform with 1% of methanol. Intensely yellow crystals are obtained from ethanol.

Fuente