Reacción #708952

Ecuación de reacción

myristic acid

carbonyl diimidazole

Unsym-dimethylhydrazine

→

title compound

Tetradecanoic acid 2,2-dimethylhydrazide

Disolventes

tetrahydrofuran

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroreacted overnight at room temperature
2. 2
   OtroThe reaction mixture is evaporated under reduced pressure
3. 3
   Otrodried in vacuo
4. 4
   Otropurified on a silica gel column
5. 5
   Otroevaporated under reduced pressure
6. 6
   Otrodried in vacuo

Procedimiento

690 mg (3 meq) of myristic acid and 486 mg (3 meq) of carbonyl diimidazole are reacted in a minimum volume of tetrahydrofuran at room temperature for 1 hour. Unsym-dimethylhydrazine (0.23 ml, 3 meq) is added and reacted overnight at room temperature. The reaction mixture is evaporated under reduced pressure, dried in vacuo and purified on a silica gel column using CH2Cl2 :CH3OH (5:1). The fractions having R6 0.76 on TLC S.G. CH2Cl2 :CH3OH (5:1) chlorine-peptide spray are combined, evaporated under reduced pressure and dried in vacuo to yield 185 mg of title compound having a m.p. of 63.5°-64.5° C.

Fuente