Reacción #70853

Ecuación de reacción

2-[1-(tert-butoxycarbonyl)piperidin-4-yl]-4,6-bis(4-fluorophenyl)-5-(4-pyridyl)pyrazolo[3,4-b]pyridine

trifluoroacetic acid

→

title compound

Rendimiento 62.0%

4,6-Bis(4-fluorophenyl)-2-(4-piperidyl)-5-(4-pyridyl)pyrazolo[3,4-b]pyridine

Rendimiento 62.0%

Disolventes

CH2Cl2

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solvent was evaporated
2. 2
   workup.DISSOLUTIONThe residue was dissolved in CHCl3
3. 3
   Lavadowashed with 1 N NaOH and brine
4. 4
   SecadoThe organic phase was dried over Na2SO4
5. 5
   Concentraciónconcentrated to dryness

Procedimiento

To a solution of 2-[1-(tert-butoxycarbonyl)piperidin-4-yl]-4,6-bis(4-fluorophenyl)-5-(4-pyridyl)pyrazolo[3,4-b]pyridine (0.62 g, 1.1 mmol, obtained in example 20) in CH2Cl2 (19 mL) under argon atmosphere and cooled to 0° C., trifluoroacetic acid (1.8 mL) was added. It was stirred at room temperature for 2.5 h. The solvent was evaporated. The residue was dissolved in CHCl3 and washed with 1 N NaOH and brine. The organic phase was dried over Na2SO4 and concentrated to dryness, to afford 319 mg of the title compound (yield: 62%).

Fuente