Reacción #708385

Ecuación de reacción

(E)-1,2,3,9-tetrahydro-6-methoxy-9-methyl-3-[(5-methyl-1H-imidazol-4-yl)methylene]-4H-carbazol-4-one

→

foam

Rendimiento 99.4%

1,2,3,9-Tetrahydro-6-methoxy-9-methyl-3-[(5-methyl-1H-imidazol-4-yl)methyl]-4H-carbazol-4-one

Rendimiento 99.4%

Disolventes

ethanol

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrowas hydrogenated at room temperature
2. 2
   FiltraciónThe mixture was filtered
3. 3
   Otroevaporated

Procedimiento

A solution of (E)-1,2,3,9-tetrahydro-6-methoxy-9-methyl-3-[(5-methyl-1H-imidazol-4-yl)methylene]-4H-carbazol-4-one (200 mg) in absolute ethanol (15 ml) was hydrogenated at room temperature and atmospheric pressure over a stirred suspension of 10% palladium oxide on carbon catalyst (50% aqueous paste; 100 mg) in absolute ethanol (5 ml). The mixture was filtered and evaporated to give a foam (ca. 200 mg) which was purified by FCC eluting with System A (200:10:1) to give the title compound (154 mg) as a solid, m.p. 227°-229°, t.l.c. (System A 200:10:1) Rf 0.26.

Fuente