Reacción #70494

Ecuación de reacción

6-[4-(4-Benzyl-phthalazin-1-yl)-piperazin-1-yl]-pyridin-3-ylamine

triethylamine

dimethylcarbamoyl chloride

→

title compound

Rendimiento 68.0%

3-{6-[4-(4-Benzyl-phthalazin-1-yl)-piperazin-1-yl]-pyridin-3-yl}-1,1-dimethyl-urea

Rendimiento 68.0%

Disolventes

CH2Cl2

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónConcentrate the crude
2. 2
   Otroreaction mixture in vacuo
3. 3
   OtroThe residue is purified by flash chromatography on silica gel (MeOH/CH2Cl2)

Procedimiento

6-[4-(4-Benzyl-phthalazin-1-yl)-piperazin-1-yl]-pyridin-3-ylamine (80 mg, 0.202 mmol), CH2Cl2 (0.5 mL), triethylamine (37 μL, 0.227 mmol), and dimethylcarbamoyl chloride (20 μL, 0.222 mmol) are combined and stirred at room temperature for 16 h. Concentrate the crude reaction mixture in vacuo. The residue is purified by flash chromatography on silica gel (MeOH/CH2Cl2) to afford the title compound (64 mg, 68%).

Fuente