Reacción #70486

Ecuación de reacción

6-{4-[4-(4-Fluoro-benzyl)-phthalazin-1-yl]-piperazin-1-yl}-nicotinic acid ethyl ester

THF

Methyl magnesium iodide

→

title compound

Rendimiento 10.0%

2-(6-{4-[4-(4-Fluoro-benzyl)-phthalazin-1-yl]-piperazin-1-yl}-pyridin-3-yl)-propan-2-ol

Rendimiento 10.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroreaction for 2 h at room temperature
2. 2
   ConcentraciónConcentrate in vacuo
3. 3
   OtroThe residue is purified by flash chromatography on silica gel (MeOH/CH2Cl2)

Procedimiento

6-{4-[4-(4-Fluoro-benzyl)-phthalazin-1-yl]-piperazin-1-yl}-nicotinic acid ethyl ester (85 mg, 0.180 mmol) is dissolved in THF (1 mL). Methyl magnesium iodide (240 μL, 3M in diethyl ether, 0.72 mmol) is added dropwise. Stir reaction for 2 h at room temperature. Concentrate in vacuo. The residue is purified by flash chromatography on silica gel (MeOH/CH2Cl2) to afford the title compound (8 mg, 10%).

Fuente