Reacción #704782

ord-987750befa8a4f81a0b4da325a5bdbb5

Ecuación de reacción

CCCCCCCC(=O)c1ccc(CCC(CC)(COC(C)=O)NC(C)=O)cc1
2-acetamido-2-ethyl-4-(4-octanoylphenyl)butyl acetate
CCOC(=O)C(CC)C(=O)OCC
ethylmalonic acid diethyl ester
CCCCCCCCc1ccc(CCC(N)(CC)CO)cc1
2-Amino-2-ethyl-4-(4-octylphenyl)butanol

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    Otroobtained
  2. 2
    Otrohydrolysis in the same manner
  3. 3
    Otroto give the subject compound

Procedimiento

In working example 77, 2-acetamido-2-ethyl-4-(4-octanoylphenyl)butyl acetate obtained by using ethylmalonic acid diethyl ester instead of propylmalonic acid diethyl ester, is subjected to reduction in the same manner as working example 2 (7) and then hydrolysis in the same manner as working example 78 to give the subject compound.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US05948820uspto-grants-1999_09