Reacción #70466

Ecuación de reacción

6-chloronicotinic acid ethyl ester

1-benzyl-4-((R)-3-methyl-piperazin-1-yl)-phthalazine

→

title compound

Rendimiento 71.1%

6-[(R)-4-(4-Benzyl-phthalazin-1-yl)-2-methyl-piperazin-1-yl]-nicotinic acid ethyl ester

Rendimiento 71.1%

Condiciones de reacción

Procedimiento

Following the above procedure, 6-chloronicotinic acid ethyl ester (100 mg, 0.54 mmol, 1.7 eq) and 1-benzyl-4-((R)-3-methyl-piperazin-1-yl)-phthalazine (100 mg, 0.31 mmol, 1.0 eq) afford the title compound as a white solid (103 mg, 71% yield).

Fuente