Reacción #70463

Ecuación de reacción

1-benzyl-4-piperazin-1-yl-phthalazine

2-chloro-5-cyanopyrimidine

MeCN

→

2-[4-(4-Benzyl-phthalazin-1-yl)-piperazin-1-yl]-pyrimidine-5-carbonitrile

Disolventes

NMP

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONare added into a microwave vial
2. 2
   Otroequipped with a stir bar
3. 3
   OtroThe vial is sealed
4. 4
   Otrothe reaction was irradiated at high level absorption in the microwave at 180° C. for 15 min
5. 5
   OtroThe compound is purified by preparative HPLC

Procedimiento

Using the general protocol, 1-benzyl-4-piperazin-1-yl-phthalazine (56 mg, 0.184 mmol) and 2-chloro-5-cyanopyrimidine (44.5 mg, 0.239 mmol) are added into a microwave vial, equipped with a stir bar, and MeCN (0.5 ml) and NMP (0.5 ml) are dispensed. The vial is sealed and the reaction was irradiated at high level absorption in the microwave at 180° C. for 15 min. The product is observed as the main peak (m/z; M+1=408). The compound is purified by preparative HPLC using a C8-254 nm method.

Fuente