Reacción #7044

Ecuación de reacción

1,1-di-indol-3-yl-butane

benzylchloride

→

product

Rendimiento 78.0%

1,1-di-(N-benzyl-indol-3-yl)-butane

Rendimiento 78.0%

Disolventes

H2O CHCl3

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe mixture thus obtained
2. 2
   workup.STIRRINGthe ultrasonic stirring
3. 3
   Otrothe chloroform phase was separated
4. 4
   Lavadowashed with a small amount of water
5. 5
   Otrodried on Na2SO4
6. 6
   Filtraciónfiltered
7. 7
   Concentraciónconcentrated to dryness
8. 8
   OtroThe end product was isolated
9. 9
   Otropurified chromatographically on silica gel
10. 10
    Lavadoeluting with hexane

Procedimiento

ST 1385 1,1-di-indol-3-yl-butane, 290 mg (1 mmol), was thoroughly mixed and blended with potassium tertbutylate (280 mg) and tetrabutylammonium bromide (20 mg). The mixture thus obtained was held under ultrasonic stirring at ambient temperature. 640 mg (5 mmol) of benzylchloride at 0° C. were then added and the ultrasonic stirring was continued for 2 hours at room temperature. At the end of this period, the reaction mixture was treated with H2O/CHCl3; the chloroform phase was separated, washed with a small amount of water, dried on Na2SO4, filtered and concentrated to dryness. The end product was isolated and purified chromatographically on silica gel, eluting with hexane:ethyl ether 95:5.351 mg of product were obtained with a 78% yield.

Fuente