Reacción #704363

Ecuación de reacción

2-amino-4-(4-piperidinyl)quinazoline

3,4-dihydroxyphenylacetic acid

→

titled compound

Rendimiento 60.2%

2-amino-4-[1-(3,4-dihydroxyphenylacetyl)-4-piperidinyl]quinazoline

Rendimiento 60.2%

Disolventes

dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solvent was removed in vacuo
2. 2
   Otrothe residue was crystallized from methanol

Procedimiento

To an ice-cold solution of 2-amino-4-(4-piperidinyl)quinazoline (600 mg, 2.63 mmol) obtained in example 11(1), 3,4-dihydroxyphenylacetic acid (530 mg, 3.16 mmol) and 4-dimethylaminopyridine (386 mg, 3.16 mmol) in dimethylformamide (20 ml) was added 1-ethyl-3-(N,N'-dimethylaminopropyl)carbodiimide hydrochloride (605 mg, 3.16 mmol) under a nitrogen atmosphere. The mixture was stirred overnight at room temperature. The solvent was removed in vacuo and the residue was crystallized from methanol to give the titled compound (599 mg).

Fuente