Reacción #70424

Ecuación de reacción

4-[2-(4-methanesulfonylphenoxymethyl)pyridin-5-yl]piperidin-1-carbonitrile

hydroxylamine

→

title compound

Rendimiento 98.0%

N-Hydroxy-4-[2-(4-methanesulfonylphenoxymethyl)-pyridin-5-yl]piperidin-1-carboxamidine

Rendimiento 98.0%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturato cool to room temperature
2. 2
   Concentraciónconcentrated under reduced pressure

Procedimiento

To a solution of 4-[2-(4-methanesulfonylphenoxymethyl)pyridin-5-yl]piperidin-1-carbonitrile (92 mg, 0.248 mmol) in ethanol (0.8 mL) was added 50% hydroxylamine solution (0.2 mL). The mixture was stirred at 60° C. for 4 hours, allowed to cool to room temperature and concentrated under reduced pressure to give the title compound (98 mg, yield 98%).

Fuente