Reacción #703592

Ecuación de reacción

hydrochloric acid

3,5-dibromo-salicylaldehyde

tert. butylamine

ammonia

→

N-tert.butyl-3,5-dibromo-2-hydroxy-benzylamine hydrochloride

Disolventes

ether

formic acid

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe precipitate formed
2. 2
   Otroto crystallize the product out

Procedimiento

7 gm of 3,5-dibromo-salicylaldehyde, 17.5 gm of tert. butylamine and 7.7 gm of formic acid were heated for 6 hours at 70°-80° C. Subsequently, the reaction mixture was admixed with aqueous 2 N ammonia, vigorously shaken, and the precipitate formed thereby was sucked off. The residue was dissolved in ethanol, acidified with ethanolic hydrochloric acid and admixed with ether in order to crystallize the product out. N-tert.butyl-3,5-dibromo-2-hydroxy-benzylamine hydrochloride, m.p. 216°-220° C (decomp.), was obtained after recrystallization from absolute ethanol/ether.

Fuente