Reacción #702832

Ecuación de reacción

sodium carbonate

( A )

1-(2,2-diethoxyethyl)-5-amino-3-methylpyrazole

sulfuric acid

→

6-methylimidazo[1,2-b]pyrazole

Rendimiento 41.0%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaunder reflux for 5 hours
2. 2
   TemperaturaAfter cooling
3. 3
   FiltraciónThe resulting mixture was filtered
4. 4
   Otrothe solvent was removed from the filtrate
5. 5
   OtroThe thus obtained residue was recrystallized

Procedimiento

The resultant (A) was heated in a mixture of 200 ml of ethanol and 80 ml of a 20% aqueous solution of sulfuric acid under reflux for 5 hours. After cooling, excess solid sodium carbonate was added thereto. The resulting mixture was filtered, and the solvent was removed from the filtrate. The thus obtained residue was recrystallized to provide 1.4 g of 6-methylimidazo[1,2-b]pyrazole. Yield was 41%.

Fuente