Reacción #70217

Ecuación de reacción

Acetophenone

3′-Hydroxy-4′-methoxyacetophenone

O-(4-cyanobenzyl)hydroxylamine hydrochloride

→

CP30283

Rendimiento 51.0%

(E)-3′-Hydroxy-4′-methoxyacetophenone O-4-Cyanobenzyl Oxime

Rendimiento 51.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter being heated for 3 h the reaction mixture
2. 2
   Temperaturawas cooled
3. 3
   Otrothe solvent removed under reduced pressure
4. 4
   FiltraciónThe ensuing solid was filtered off
5. 5
   Lavadowashed with cold isopropanol (3.0 mL)

Procedimiento

Acetophenone 12 (30 mg, 0.181 mmol) was condensed with O-(4-cyanobenzyl)hydroxylamine hydrochloride (35) (37 mg, 0.200 mmol) according to the general procedure II-B defined above. After being heated for 3 h the reaction mixture was cooled and the solvent removed under reduced pressure. The ensuing solid was filtered off and washed with cold isopropanol (3.0 mL) to afford the title compound CP30283 (27 mg, 51%) as a white solid, m.p. 125.9-129.7° C.

Fuente