Reacción #70210

Ecuación de reacción

3′-Hydroxyacetophenone

compound 19

O-(4-Nitrobenzyl)hydroxylamine Hydrochloride

→

CP30260

Rendimiento 82.0%

(E)-3′-Hydroxyacetophenone O-4-Nitrobenzyl Oxime

Rendimiento 82.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter being heated for 3 h the reaction mixture
2. 2
   Temperaturawas cooled
3. 3
   Otrothe solvent removed under reduced pressure
4. 4
   FiltraciónThe resulting solid was filtered off
5. 5
   Lavadowashed with cold isopropanol (3.0 mL)

Procedimiento

3′-Hydroxyacetophenone (24) (150 mg, 1.10 mmol) was condensed with compound 19 (248 mg, 1.21 mmol) according to the general procedure II-A defined above. After being heated for 3 h the reaction mixture was cooled and the solvent removed under reduced pressure. The resulting solid was filtered off and washed with cold isopropanol (3.0 mL) to afford the title compound CP30260 (257 mg, 82%) as a white solid, m.p. 123.6-125.3° C.

Fuente