Reacción #70205

Ecuación de reacción

Acetophenone

compound 19

O-(4-Nitrobenzyl)hydroxylamine Hydrochloride

→

CP30252

Rendimiento 77.0%

(E)-Acetophenone O-4-Nitrobenzyl Oxime

Rendimiento 77.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter heating the reaction mixture for 2 h it
2. 2
   Temperaturawas cooled
3. 3
   Otrothe solvent removed under reduced pressure
4. 4
   FiltraciónThe resulting solid was filtered off
5. 5
   Lavadowashed with cold isopropanol (3.0 mL)

Procedimiento

Acetophenone (20) (150 mg, 1.25 mmol) was condensed with compound 19 (280 mg, 1.37 mmol) according to the general procedure II-A defined above. After heating the reaction mixture for 2 h it was cooled and the solvent removed under reduced pressure. The resulting solid was filtered off and washed with cold isopropanol (3.0 mL) to afford the title compound CP30252 (258 mg, 77%) as a pale-yellow solid, m.p. 91.3-92.3° C.

Fuente