Reacción #700677

Ecuación de reacción

water

3-bromo-4-chloro-8-(2,6-dichlorobenzoylamino)quinoline

2-mercaptoimidazole

potassium carbonate

→

3-bromo-8-(2,6-dichlorobenzoylamino)-4-(imidazol-2-ylthio)quinoline

Rendimiento 63.9%

Disolventes

N-methylpyrrolidone

Condiciones de reacción

Tratamiento posterior

1. 1
   Filtraciónthe resulting precipitate was collected by filtration
2. 2
   Lavadowashed with water and ethanol

Procedimiento

To a solution of 3-bromo-4-chloro-8-(2,6-dichlorobenzoylamino)quinoline (120 mg) in N-methylpyrrolidone were added 2-mercaptoimidazole (33.5 mg) and potassium carbonate (50.1 mg), and the mixture was stirred for 40 minutes at ambient temperature, for 1 hour at 40° C., for 1 hour at 80° C. and for 1 hour at 90° C. To the mixture was added water, and the resulting precipitate was collected by filtration and washed with water and ethanol to give 3-bromo-8-(2,6-dichlorobenzoylamino)-4-(imidazol-2-ylthio)quinoline (88.0 mg).

Fuente