Reacción #69981

Ecuación de reacción

4-(4-bromophenyl)piperidin-4-ol

triethylamine

methanesulphonyl chloride

→

4-(4-bromophenyl)-1-(methanesulphonyl)piperidin-4-ol

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   LavadoIt is washed with water
2. 2
   SecadoThe organic phase is dried over sodium sulphate
3. 3
   Otroevaporated under reduced pressure
4. 4
   OtroThe crude product obtained
5. 5
   Otrois chromatographed on silica gel, elution

Procedimiento

1 g of 4-(4-bromophenyl)piperidin-4-ol is placed in 20 ml of dichloromethane. 0.65 ml of triethylamine and then 0.33 ml of methanesulphonyl chloride are added. The reaction mixture is stirred at ambient temperature for 2 h. It is washed with water and then with a saturated aqueous sodium chloride solution. The organic phase is dried over sodium sulphate and then evaporated under reduced pressure. The crude product obtained is chromatographed on silica gel, elution being carried out with a dichloromethane/methanol (99/1) solvent mixture. 1.1 g of 4-(4-bromophenyl)-1-(methanesulphonyl)piperidin-4-ol are obtained.

Fuente